The history of aspirin: the discoveries that changed contemporary medicine andrew szczeklik ancestors of aspirin for millennia, pain, fever, and inflammation were treated with plants. The idea of using aspirin to prevent clotting diseases (such as heart attacks and strokes) was revived in the 1960s, when medical researcher harvey weiss found that aspirin had an anti-adhesive effect on blood platelets (and unlike other potential antiplatelet drugs, aspirin had low toxicity. Aspirin is readily broken down in the body to salicylic acid, which itself has anti-inflammatory, antipyretic, and analgesic effects in 2012, salicylic acid was found to activate amp-activated protein kinase, which has been suggested as a possible explanation for some of the effects of both salicylic acid and aspirin.
Prostaglandins were found to be responsible for pain and blood clotting in june 1971 nature published a seminal paper by john vane and priscilla piper, “inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs” the antiplatelet activity of aspirin has resulted in a new use for an old drug.
Aspirin has a great history of development which could be considered to have begun in the 3000bc where it was recorded that remedies from the willow tree were the most useful for the treatment of many ailments.
Reminder: these notes are meant to supplement, not replace, the laboratory manual synthesis of aspirin notes history and application aspirin is one of the most commonly used drugs in the world with approximately 100.
Aspirin represents one of humankind’s oldest pharmaceutical agents and continues to be a mainstay therapy for a variety of indications like all drugs, aspirin can be toxic at high doses (greater than 150 milligrams per kilogram body weight), but the benefits of aspirin clearly outweigh the risks.